Abstract：
Molluscum contagiosum virus is an important human skin pathogen: it can cause disfigurement and suffering in children, in adults it is less common and often sexually transmitted. Extensive and persistent skin infection with the virus can indicate underlying immunodeficiency. Traditional ablative therapies have not been compared directly with newer immune-modulating and specific antiviral therapies. Advances in research raise the prospect of new approaches to treatment informed by the biology of the virus; in human skin, the infection is localised in the epidermal layers, where it induces a typical, complex hyperproliferative lesion with an abundance of virus particles but a conspicuous absence of immune effectors. Functional studies of the viral genome have revealed effects on cellular pathways involved in the cell cycle, innate immunity, inflammation, and cell death. Extensive lesions caused by molluscum contagiosum can occur in patients with DOCK8 deficiency-a genetic disorder affecting migration of dendritic and specialised T cells in skin. Sudden disappearance of lesions is the consequence of a vigorous immune response in healthy people. Further study of the unique features of infection with molluscum contagiosum virus could give fundamental insight into the nature of skin immunity.
摘要：
传染性软疣病毒是一种重要的人类皮肤病原体:它会导致儿童毁容和痛苦，在成年人中，这种情况不太常见，而且经常通过性传播。病毒的广泛和持续的皮肤感染可能表明潜在的免疫缺陷。传统的消融疗法尚未直接与新的免疫调节和特异性抗病毒疗法进行比较。研究的进展提高了新的治疗方法的前景，了解病毒的生物学;在人类皮肤，感染位于表皮层，它诱导了一个典型的，复杂的过度增生性病变，病毒颗粒丰富，但明显缺乏免疫效应物。病毒基因组的功能研究揭示了对细胞周期中涉及的细胞途径的影响，先天免疫,炎症,细胞死亡。传染性软体动物引起的广泛病变可发生在DOCK8缺乏症患者中，DOCK8缺乏症是一种影响皮肤中树突状和特化T细胞迁移的遗传疾病。病变的突然消失是健康人强烈免疫反应的结果。对传染性软疣病毒感染的独特特征的进一步研究可以从根本上了解皮肤免疫的性质。
