Abstract:
Endometrial stromal sarcomas are rare malignant tumors of the uterus, and most of the information available in literature is based on small series or case reports. A proper preoperative diagnosis is difficult and in most cases the diagnosis is confirmed after hysterectomy for a presumed benign disease. Endometrial sampling, ultrasound, and magnetic resonance imaging can provide diagnostic clues. Total hysterectomy with bilateral salpingo-oopherectomy is the main line of management and for early disease complete cure is a reality. Ovarian conservation may be possible in young women with early stage disease and the role of lymphadenectomy is controversial. Adjuvant hormone therapy in the form of progesterone, gonadotropin releasing hormone analogues, and aromatase inhibitors are found to be effective in preventing recurrences. Hormone therapy, radiotherapy and surgical excision of the metastasis are recommended for recurrences.
摘要:
子宫内膜间质肉瘤是罕见的子宫恶性肿瘤,文献中的大多数信息都是基于小系列或病例报告。正确的术前诊断是困难的,在大多数情况下,在子宫切除术后对假定的良性疾病进行诊断。子宫内膜取样,超声,磁共振成像可以提供诊断线索。全子宫切除术和双侧输卵管切除术是治疗的主线,早期疾病的完全治愈是现实。在患有早期疾病的年轻女性中,保留卵巢是可能的,淋巴结清扫术的作用是有争议的。黄体酮形式的辅助激素治疗,促性腺激素释放激素类似物,发现芳香酶抑制剂可有效预防复发。激素治疗,对于复发,建议放疗和手术切除转移瘤。