Abstract：
OBJECTIVE: Squamous cell carcinoma (SCC) is the most prevalent malignant neoplasm of the oral cavity and oral verrucous carcinoma (OVC) is a verrucous variant of SCC. The purpose of this study was to examine the clinical classification of OVC and see for any difference in the biological behavior between OVC and CSS.
METHODS: OVC and SCC were divided into 5 groups: the exogenic type of OVC (eOVC), cystoid type of OVC (cOVC) and infiltrative type of OVC (iOVC); well differentiated SCC (wdSCC), and medium/poorly differentiated SCC (m/pdSCC). A normal mucosa (NM) group was also created and studied. Stereology was used to measure and describe the morphological parameters of the nucleus to cytoplasm ratio (Vnp), desmosomes, mitochondria, etc. Analysed were also the nucleus volume density (Vv), Vnp, desmosomes and intracellular desmosomes number density (Nv), which were observed by stereology.
RESULTS: We noticed some statistically significant differences in the morphological parameters among the 6 groups including the Vv (p<0.05), the Vnp (p<0.05), the number density of desmosomes (p<0.05), and the Nv (p<0.05).
CONCLUSIONS: This study provides a theoretical basis for the clinical diagnosis and therapy of OVC.
METHODS: OVC and SCC were divided into 5 groups: the exogenic type of OVC (eOVC), cystoid type of OVC (cOVC) and infiltrative type of OVC (iOVC); well differentiated SCC (wdSCC), and medium/poorly differentiated SCC (m/pdSCC). A normal mucosa (NM) group was also created and studied. Stereology was used to measure and describe the morphological parameters of the nucleus to cytoplasm ratio (Vnp), desmosomes, mitochondria, etc. Analysed were also the nucleus volume density (Vv), Vnp, desmosomes and intracellular desmosomes number density (Nv), which were observed by stereology.
RESULTS: We noticed some statistically significant differences in the morphological parameters among the 6 groups including the Vv (p<0.05), the Vnp (p<0.05), the number density of desmosomes (p<0.05), and the Nv (p<0.05).
CONCLUSIONS: This study provides a theoretical basis for the clinical diagnosis and therapy of OVC.
摘要：
目的：鳞状细胞癌（SCC）是口腔最常见的恶性肿瘤，口腔疣状癌（OVC）是SCC的疣状变体。这项研究的目的是检查OVC的临床分类，并查看OVC和CSS之间生物学行为的任何差异。
方法：将OVC和SCC分为5组：外生型OVC（eOVC），囊样型OVC（cOVC）和浸润型OVC（iOVC）；分化良好的SCC（wdSCC），和中等/低分化SCC(m/pdSCC)。还创建并研究了正常粘膜（NM）组。体视学用于测量和描述细胞核与细胞质比（Vnp）的形态参数，桥粒,线粒体,等。还分析了细胞核体积密度(Vv)，Vnp,桥粒和细胞内桥粒数密度（Nv），这是通过体视学观察到的。
结果：我们注意到包括Vv在内的6组之间的形态学参数存在统计学上的显着差异（p<0.05），Vnp(p<0.05)，桥粒的数量密度（p<0.05），和Nv(p<0.05)。
结论：本研究为OVC的临床诊断和治疗提供了理论依据。
方法：将OVC和SCC分为5组：外生型OVC（eOVC），囊样型OVC（cOVC）和浸润型OVC（iOVC）；分化良好的SCC（wdSCC），和中等/低分化SCC(m/pdSCC)。还创建并研究了正常粘膜（NM）组。体视学用于测量和描述细胞核与细胞质比（Vnp）的形态参数，桥粒,线粒体,等。还分析了细胞核体积密度(Vv)，Vnp,桥粒和细胞内桥粒数密度（Nv），这是通过体视学观察到的。
结果：我们注意到包括Vv在内的6组之间的形态学参数存在统计学上的显着差异（p<0.05），Vnp(p<0.05)，桥粒的数量密度（p<0.05），和Nv(p<0.05)。
结论：本研究为OVC的临床诊断和治疗提供了理论依据。
