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Abstract：
PIWI-interacting RNAs (piRNAs) are a distinct class of small non-coding RNAs that form the piRNA-induced silencing complex (piRISC) in the germ line of many animal species. The piRISC protects the integrity of the genome from invasion by \'genomic parasites\'--transposable elements--by silencing them. Owing to their limited expression in gonads and their sequence diversity, piRNAs have been the most mysterious class of small non-coding RNAs regulating RNA silencing. Now, much progress is being made into our understanding of their biogenesis and molecular functions, including the specific subcellular compartmentalization of the piRNA pathway in granular cytoplasmic bodies.
摘要：
PIWI相互作用RNA(piRNA)是一类独特的小的非编码RNA,其在许多动物物种的种系中形成piRNA诱导的沉默复合物(piRISC)。piRISC通过沉默它们来保护基因组的完整性免受“基因组寄生虫”-转座元素的入侵。由于它们在性腺中的表达有限和序列多样性，piRNA是调节RNA沉默的最神秘的一类小的非编码RNA。现在,我们对它们的生物发生和分子功能的理解正在取得很大进展，包括颗粒细胞质体中piRNA途径的特定亚细胞区室化。
