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Abstract：
This report offers a consensus opinion on the diagnosis, epidemiology, treatment, and prevention of leptospirosis in dogs, an important zoonosis. Clinical signs of leptospirosis in dogs relate to development of renal disease, hepatic disease, uveitis, and pulmonary hemorrhage. Disease may follow periods of high rainfall, and can occur in dogs roaming in proximity to water sources, farm animals, or wildlife, or dogs residing in suburban environments. Diagnosis is based on acute and convalescent phase antibody titers by the microscopic agglutination test (MAT), with or without use of polymerase chain reaction assays. There is considerable interlaboratory variation in MAT results, and the MAT does not accurately predict the infecting serogroup. The recommended treatment for optimal clearance of the organism from renal tubules is doxycycline, 5 mg/kg p.o. q12h, for 14 days. Annual vaccination can prevent leptospirosis caused by serovars included in the vaccine and is recommended for dogs at risk of infection.
摘要：
这份报告提供了关于诊断的共识意见，流行病学,治疗,和预防狗的钩端螺旋体病，一种重要的动物传染病.犬钩端螺旋体病的临床体征与肾脏疾病的发展有关，肝病,葡萄膜炎,和肺出血。疾病可能会伴随着高降雨量，可能发生在靠近水源漫游的狗身上，农场动物,或者野生动物，或者居住在郊区环境中的狗。诊断基于显微镜凝集试验（MAT）的急性期和恢复期抗体滴度，使用或不使用聚合酶链反应测定。MAT结果存在相当大的实验室间差异，MAT不能准确预测感染血清群。从肾小管中最佳清除生物体的推荐治疗方法是多西环素，5mg/kgp.o.q12h，14天。每年接种疫苗可以预防由疫苗中包含的血清变型引起的钩端螺旋体病，建议用于有感染风险的狗。
