Mesh : Animals Cell Membrane / drug effects metabolism Cell Membrane Permeability / drug effects Cells, Cultured Female Flow Cytometry Hydrogen Peroxide / pharmacology Ionophores / pharmacology Membrane Potentials / drug effects Myometrium / cytology drug effects metabolism Nitric Oxide Donors / pharmacology Nitrogen Oxides / pharmacology Nitroprusside / pharmacology Potassium / metabolism Sarcolemma / drug effects metabolism Swine Valinomycin / pharmacology

来  源:   DOI:

Abstract:
Prospects of the use of flow cytometry analysis for investigation of forming K(+)- equilibrium membrane potential on the experimental model of myometrium plasma membrane vesicles in the presence of valinomycine using potential-sensitive probe of DiOC6(3). Transmembrane potential magnitude corresponds to magnitude by Nernst\'s equation. H2O2 and NO2-, probably, increase permeability of membrane for K+ and result in potential dissipation. Given effect is not shown for sodium nitroprusside. The obtained results confirm an assumption as to enhancing the passive transport for K+ through sarcolemma under the action of these substances, that can lead to membrane repolarisation and decline of the level of its excitability.
摘要:
暂无翻译
公众号