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Abstract：
The extracellular signal-regulated kinase (ERK) pathway is a member of the mitogen-activated protein kinase (MAPK) superfamily, which is an important, highly conserved family of enzymes associated with cell membrane receptors and regulative targets. In the central nervous system, there is almost no mature neuronal proliferation and differentiation, but the regulation of MAPK and its upstream and downstream molecular pathways is still widespread, with the ERK signaling pathway being one of the most actively studied signal transduction pathways. It is activated by a variety of cell growth factors and substances which promote mitotic activity, and transmits extracellular signals from the cell surface to the nucleus, which transmission plays an important role in the process of cell proliferation and differentiation. In recent years, accumulating evidence has shown that the ERK signaling pathway has an important link with the higher functions of learning and memory.
摘要：
细胞外信号调节激酶（ERK）途径是丝裂原活化蛋白激酶（MAPK）超家族的成员，这是一个重要的，与细胞膜受体和调节靶标相关的高度保守的酶家族。在中枢神经系统中，几乎没有成熟的神经元增殖和分化，但是MAPK及其上游和下游分子途径的调控仍然很普遍，ERK信号通路是研究最活跃的信号转导通路之一。它被多种细胞生长因子和促进有丝分裂活性的物质激活，并将细胞外信号从细胞表面传递到细胞核，在细胞增殖和分化过程中起着重要的作用。近年来,越来越多的证据表明,ERK信号通路与学习记忆的高级功能有着重要的联系。
