Mesh : Bacterial Proteins / chemistry Bacterial Typing Techniques / methods Bacteriophages / immunology pathogenicity Computational Biology / methods Databases, Genetic Evolution, Molecular Immunity, Active Molecular Sequence Data Prokaryotic Cells / immunology virology Protein Sorting Signals / physiology

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Abstract:
CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats), the basis of spoligotyping technology, can provide prokaryotes with heritable adaptive immunity against phages\' invasion. Studies on CRISPR loci and their associated elements, including various CAS (CRISPR-associated) proteins and leader sequences, are still in its infant period. We introduce the brief history\', structure, function, bioinformatics research and application of this amazing immunity system in prokaryotic organism for inspiring more scientists to find their interest in this developing topic.
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