PDF(Pubmed)
Abstract：
Wound healing requires a complex series of reactions and interactions among cells and their mediators, resulting in an overlapping series of events including coagulation, inflammation, epithelialization, formation of granulation tissue, matrix and scar formation. Cytokines and chemokines promote inflammation, angiogenesis, facilitate the passage of leukocytes from circulation into the tissue, and contribute to the regulation of epithelialization. They integrate inflammatory events and reparative processes that are important for modulating wound healing. Thus both cytokines and chemokines are important targets for therapeutic intervention. The chemokine-mediated regulation of angiogenesis is highly sophisticated, fine tuned, and involves pro-angiogenic chemokines, including CXCL1-3, 5-8 and their receptors, CXCR1 and CXCR2. CXCL1 and CXCR2 are expressed in normal human epidermis and are further induced during the wound healing process of human burn wounds, especially during the inflammatory, epithelialization and angiogenic processes. Human skin explant studies also show CXCR2 is expressed in wounded keratinocytes and Th/1/Th2 cytokine modulation of CXCR2 expression correlates with proliferation of epidermal keratinocytes. Murine excision wound healing, chemical burn wounds and skin organ culture systems are valuable models for examining the role of inflammatory cytokines and chemokines in wound healing.
摘要：
伤口愈合需要细胞及其介质之间一系列复杂的反应和相互作用，导致一系列重叠的事件，包括凝血，炎症,上皮化,肉芽组织的形成，基质和疤痕的形成。细胞因子和趋化因子促进炎症，血管生成,促进白细胞从循环进入组织，并有助于调节上皮形成。它们整合了对于调节伤口愈合重要的炎症事件和修复过程。因此,细胞因子和趋化因子都是治疗性干预的重要靶标。趋化因子介导的血管生成调节是非常复杂的，微调，涉及促血管生成趋化因子，包括CXCL1-3，5-8和它们的受体，CXCR1和CXCR2。CXCL1和CXCR2在正常人表皮中表达，并在人烧伤创面愈合过程中进一步诱导，尤其是在炎症期间，上皮形成和血管生成过程。人皮肤外植体研究还显示CXCR2在受伤的角质形成细胞中表达,并且CXCR2表达的Th/1/Th2细胞因子调节与表皮角质形成细胞的增殖相关。鼠切除伤口愈合，化学烧伤伤口和皮肤器官培养系统是检验炎性细胞因子和趋化因子在伤口愈合中的作用的有价值的模型。
