雌激素缺乏增加破骨细胞生成 , 上调 T 细胞活性 : 骨质疏松症的关键机制。
Mesh : Cells, Cultured Coculture Techniques Enzyme-Linked Immunosorbent Assay Estrogens / deficiency Female Flow Cytometry Humans Lymphocyte Activation Osteoclasts / pathology Osteoporosis / etiology metabolism pathology Postmenopause RANK Ligand / metabolism Reverse Transcriptase Polymerase Chain Reaction T-Lymphocytes / physiology Tumor Necrosis Factor-alpha / metabolism Up-Regulation
来 源:
DOI:10.1016/j.bone.2008.02.017
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