Abstract：
Acute basophilic leukaemia is an uncommon form of acute leukaemia, rarely occurring as de novo disease. Due to rarity of the disease, consistent diagnostic criteria for the identification of this entity still remain the topic of discussion. Immunophenotypic profile, electron microscopy and cytogenetic analysis in addition to morphological features, are said to be highly desirable for correct identification of this entity. In set-up like ours, where such facilities are either not available or not in reach of the patients due to financial constraints, morphological features and simple technique like demonstration of metachromasia in blasts with toluidine blue stain remain the most useful diagnostic tool for identification of this rare condition. We present a case of acute basophilic leukaemia with (11q23)-MLL gene rearrangement, in an 18-year-old male with review of literature and discussion of diagnostic criteria.
摘要：
急性嗜碱性白血病是一种罕见的急性白血病，很少作为新生疾病发生。由于罕见的疾病，识别该实体的一致诊断标准仍然是讨论的主题。免疫表型，电子显微镜和细胞遗传学分析，除了形态学特征，据说对于正确识别这个实体是非常可取的。在像我们这样的设置中，如果由于经济拮据而无法获得此类设施或患者无法获得此类设施，形态学特征和简单的技术，例如在甲苯胺蓝染色的原始细胞中显示异色性，仍然是鉴定这种罕见疾病的最有用的诊断工具。我们介绍了一例急性嗜碱性白血病（11q23）-MLL基因重排，在一名18岁男性中，回顾了文献并讨论了诊断标准。
