Mesh : Adolescent Adult Aged Algorithms Antibodies, Bacterial / blood Bacterial Typing Techniques Child Child, Preschool Corynebacterium / classification isolation & purification Corynebacterium diphtheriae / isolation & purification Diphtheria / diagnosis immunology microbiology Diphtheria Toxin / immunology Female Humans Laboratories Male Middle Aged Serologic Tests Specimen Handling

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Abstract:
These guidelines represent an application of the World Health Organization European Region\'s manual for the laboratory diagnosis of diphtheria for laboratories in the United Kingdom (UK), but they could be applied to laboratories overseas. The manual was rewritten in response to the re-emergence of diphtheria in eastern Europe and the emergence of other infections caused by Corynebacterium diphtheriae and C. ulcerans in the UK and overseas. The guidelines summarise our current recommendations and procedures for the microbiological diagnosis of infections caused by toxigenic and non-toxigenic isolates of corynebacteria, with particular reference to C. diphtheriae and C. ulcerans.
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